Journal Title：Journal Of Gene Medicine

The aims and scope of The Journal of Gene Medicine include cutting-edge science of gene transfer and its applications in gene and cell therapy, genome editing with precision nucleases, epigenetic modifications of host genome by small molecules, siRNA, microRNA and other noncoding RNAs as therapeutic gene-modulating agents or targets, biomarkers for precision medicine, and gene-based prognostic/diagnostic studies.

Key areas of interest are the design of novel synthetic and viral vectors, novel therapeutic nucleic acids such as mRNA, modified microRNAs and siRNAs, antagomirs, aptamers, antisense and exon-skipping agents, refined genome editing tools using nucleic acid /protein combinations, physically or biologically targeted delivery and gene modulation, ex vivo or in vivo pharmacological studies including animal models, and human clinical trials.

Papers presenting research into the mechanisms underlying transfer and action of gene medicines, the application of the new technologies for stem cell modification or nucleic acid based vaccines, the identification of new genetic or epigenetic variations as biomarkers to direct precision medicine, and the preclinical/clinical development of gene/expression signatures indicative of diagnosis or predictive of prognosis are also encouraged.

《基因醫(yī)學(xué)雜志》的目標(biāo)和范圍包括基因轉(zhuǎn)移的前沿科學(xué)及其在基因和細(xì)胞治療中的應(yīng)用、使用精準(zhǔn)核酸酶的基因組編輯、小分子對(duì)宿主基因組的表觀遺傳修飾、siRNA、microRNA 和其他非編碼 RNA 作為治療性基因調(diào)節(jié)劑或靶標(biāo)、精準(zhǔn)醫(yī)學(xué)的生物標(biāo)志物以及基于基因的預(yù)后/診斷研究。

主要關(guān)注領(lǐng)域包括新型合成和病毒載體的設(shè)計(jì)、新型治療性核酸（如 mRNA、修飾的 microRNA 和 siRNA）、微小RNA拮抗劑、適體、反義和外顯子跳躍劑、使用核酸/蛋白質(zhì)組合的精細(xì)基因組編輯工具、物理或生物靶向遞送和基因調(diào)節(jié)、體外或體內(nèi)藥理學(xué)研究（包括動(dòng)物模型）和人體臨床試驗(yàn)。

論文介紹了基因藥物轉(zhuǎn)移和作用機(jī)制的研究、干細(xì)胞修飾或核酸疫苗新技術(shù)的應(yīng)用、新基因的鑒定或表觀遺傳變異作為生物標(biāo)志物來(lái)指導(dǎo)精準(zhǔn)醫(yī)療，并鼓勵(lì)指示診斷或預(yù)測(cè)預(yù)后的基因/表達(dá)特征的臨床前/臨床開(kāi)發(fā)。

Journal Of Gene Medicine創(chuàng)刊于1999年，由WILEY出版商出版，影響因子指數(shù)3.258，該期刊近期沒(méi)有被列入國(guó)際期刊預(yù)警名單，廣大學(xué)者值得一試。