Journal Title：Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis

Mutation Research (MR) provides a platform for publishing all aspects of DNA mutations and epimutations, from basic evolutionary aspects to translational applications in genetic and epigenetic diagnostics and therapy. Mutations are defined as all possible alterations in DNA sequence and sequence organization, from point mutations to genome structural variation, chromosomal aberrations and aneuploidy. Epimutations are defined as alterations in the epigenome, i.e., changes in DNA methylation, histone modification and small regulatory RNAs.

MR publishes articles in the following areas:

Of special interest are basic mechanisms through which DNA damage and mutations impact development and differentiation, stem cell biology and cell fate in general, including various forms of cell death and cellular senescence.

The study of genome instability in human molecular epidemiology and in relation to complex phenotypes, such as human disease, is considered a growing area of importance.

Mechanisms of (epi)mutation induction, for example, during DNA repair, replication or recombination; novel methods of (epi)mutation detection, with a focus on ultra-high-throughput sequencing.

Landscape of somatic mutations and epimutations in cancer and aging.

Role of de novo mutations in human disease and aging; mutations in population genomics.

Interactions between mutations and epimutations.

The role of epimutations in chromatin structure and function.

Mitochondrial DNA mutations and their consequences in terms of human disease and aging.

Novel ways to generate mutations and epimutations in cell lines and animal models.

突變研究 (MR) 提供了一個平臺，用于發(fā)布 DNA 突變和表觀突變的各個方面，從基本的進化方面到遺傳和表觀遺傳診斷和治療中的轉(zhuǎn)化應(yīng)用。突變被定義為 DNA 序列和序列組織的所有可能改變，從點突變到基因組結(jié)構(gòu)變異、染色體畸變和非整倍性。表觀突變被定義為表觀基因組的改變，即 DNA 甲基化、組蛋白修飾和小調(diào)節(jié) RNA 的變化。

MR 在以下領(lǐng)域發(fā)表文章：

特別令人感興趣的是 DNA 損傷和突變影響發(fā)育和分化、干細胞生物學(xué)和細胞命運的基本機制，包括各種形式的細胞死亡和細胞衰老。

人類分子流行病學(xué)中基因組不穩(wěn)定性的研究以及與人類疾病等復(fù)雜表型的關(guān)系被認為是一個日益重要的領(lǐng)域。

（表觀）突變誘導(dǎo)機制，例如在 DNA 修復(fù)、復(fù)制或重組過程中；檢測（表觀）突變的新方法，重點是超高通量測序。

癌癥和衰老中的體細胞突變和表觀突變概況。

新生突變在人類疾病和衰老中的作用；群體基因組學(xué)中的突變。

突變和表觀突變之間的相互作用。

表觀突變在染色質(zhì)結(jié)構(gòu)和功能中的作用。

線粒體 DNA 突變及其對人類疾病和衰老的影響。

在細胞系和動物模型中產(chǎn)生突變和表觀突變的新方法。

Mutation Research-fundamental And Molecular Mechanisms Of Mutagenesis創(chuàng)刊于1964年，由Elsevier出版商出版，收稿方向涵蓋生物 - 毒理學(xué)全領(lǐng)域，此期刊水平偏中等偏靠后，在所屬細分領(lǐng)域中專業(yè)影響力一般，過審相對較易，如果您文章質(zhì)量佳，選擇此期刊，發(fā)表機率較高。平均審稿速度 偏慢,4-8周 ，影響因子指數(shù)1.5，該期刊近期沒有被列入國際期刊預(yù)警名單，廣大學(xué)者值得一試。